Enter the vial size and the water you added to get the concentration and the micrograms carried by each unit on a U-100 syringe; further down, the same solution is expressed as micrograms in every 0.1 mL for a nasal solution. VIP has no stated dose for any route, so this page does the arithmetic, not the recommendation. The compound itself is covered in the VIP guide.
A 10 mg vial of VIP reconstituted with 2 mL of bacteriostatic water gives a concentration of 5.0 mg/mL, or 50 mcg per unit on a U-100 syringe.
Defaults: 10 mg is the most common labelled vial among the VIP tests on file, 21 Sep 2026 (49 of 77); 2 mL was chosen for simple arithmetic and is not a sourced volume. Peptigrity publishes no VIP dose, so the dose field starts empty.
Draw the syringe up to
Enter your own amount to see the draw. Add 2 mL of water to your 10 mg vial first.
VIP has 77 independent lab tests on file at Peptigrity, averaging 99.38% HPLC purity across the tests that report one. Purity is not net content: a clean certificate confirms what is in a vial, not how much. See the VIP lab-test records.
VIP (vasoactive intestinal peptide) is a 28-amino-acid neuropeptide that binds the VPAC1 and VPAC2 receptors, producing vasodilation, smooth-muscle relaxation, immune modulation and circadian effects. The human evidence is Phase 2 research — sarcoidosis, ARDS, asthma — with mixed results, plus use in the chronic inflammatory response syndrome (CIRS) framework, which the compound page describes as contested in mainstream medicine. The page names the routes used in research (intranasal, subcutaneous and intravenous) but states no quantity for any of them, and it declines to give one. A calculator that printed a VIP dose would be inventing the number the evidence does not supply.
The table summarises what the VIP compound page states (last updated August 2026).
| Question | What the compound page states | Evidence level |
|---|---|---|
| What is it? | A 28-amino-acid neuropeptide acting on the VPAC1 and VPAC2 G-protein-coupled receptors | Established neuropeptide biology |
| Human studies? | Phase 2 trials in sarcoidosis, ARDS, asthma and other inflammatory conditions, with mixed results | Phase 2 |
| Which routes? | Intranasal, subcutaneous and intravenous are named as routes used in research | Named, no quantity attached |
| An approved dose? | Not FDA-approved for any indication (as of August 2026) | None |
| A research dose? | None stated for any route | None — declined |
One practical consequence: native VIP has a half-life of minutes, and the compound page notes that intranasal formulations carry stability and excipient considerations that basic peptide HPLC does not address. The arithmetic on this page converts milligrams in a vial into a concentration; it says nothing about how a solution behaves once mixed, or about the formulation a clinical product would use.
A nasal solution is not measured in syringe units, so the honest output for that route is the solution's strength. A 10 mg vial with 2 mL of water holds 10 ÷ 2 = 5 mg/mL. One-tenth of a millilitre of that solution carries 5 mg/mL × 0.1 mL = 0.5 mg, which is 500 mcg in every 0.1 mL. With 5 mL in the same vial it is 10 ÷ 5 = 2 mg/mL, or 200 mcg in every 0.1 mL.
No spray volume is filled in: the VIP compound page states none, so the per-spray figure appears only when you enter the volume your own pump's label gives. The 2 mL default was chosen for simple arithmetic and is not a sourced volume.
The table shows the micrograms in every 0.1 mL for each vial size at three water volumes. It is arithmetic, so it has no date; the vial sizes are the labelled sizes this calculator offers for VIP.
| Vial size | With 1 mL of water | With 2 mL of water | With 5 mL of water |
|---|---|---|---|
| 5 mg | 5 mg/mL · 500 mcg per 0.1 mL | 2.5 mg/mL · 250 mcg per 0.1 mL | 1 mg/mL · 100 mcg per 0.1 mL |
| 10 mg | 10 mg/mL · 1000 mcg per 0.1 mL | 5 mg/mL · 500 mcg per 0.1 mL | 2 mg/mL · 200 mcg per 0.1 mL |
Converting 0.1 mL into sprays needs the volume your pump delivers per actuation. The compound page states no spray volume, and a borrowed one would be an invented number, so this page does not supply it.
The table converts reference quantities to syringe units at the default of 5.0 mg/mL (10 mg of VIP in 2 mL), and counts how many draws of each a vial holds. Every row is arithmetic, not a dose: read the units for the amount you already intend to measure.
| Quantity | Draw at 5.0 mg/mL | Volume | Draws from a 5 mg vial | Draws from a 10 mg vial |
|---|---|---|---|---|
| 50 mcg | 1.0 units | 0.01 mL | 100 | 200 |
| 100 mcg | 2.0 units | 0.02 mL | 50 | 100 |
| 250 mcg | 5.0 units | 0.05 mL | 20 | 40 |
| 500 mcg | 10.0 units | 0.10 mL | 10 | 20 |
| 1 mg | 20.0 units | 0.20 mL | 5 | 10 |
The same VIP quantity lands on a different mark depending on how much water went into the vial. Read down the column for the concentration you actually mixed; a units figure carried across from another column is simply wrong.
| Quantity | At 10 mg/mL (10 mg + 1 mL) | At 5.0 mg/mL (10 mg + 2 mL) | At 2.0 mg/mL (10 mg + 5 mL) |
|---|---|---|---|
| 50 mcg | 0.5 units | 1.0 units | 2.5 units |
| 100 mcg | 1.0 units | 2.0 units | 5.0 units |
| 250 mcg | 2.5 units | 5.0 units | 12.5 units |
| 500 mcg | 5.0 units | 10.0 units | 25.0 units |
| 1 mg | 10.0 units | 20.0 units | 50.0 units |
Every cell is the same arithmetic: units = (quantity in mg ÷ concentration in mg/mL) × 100 on a U-100 syringe. More water spreads the same mass over more units, which is the fix when a small quantity would otherwise sit at two or three units, where a one-unit misread is a large error.
Each VIP vial holds as many draws as its labelled mass divided by the quantity per draw; the water volume changes nothing about it. The grid counts draws, not weeks — this page states no frequency.
| Vial size | At 50 mcg | At 100 mcg | At 250 mcg | At 500 mcg | At 1 mg |
|---|---|---|---|---|---|
| 5 mg | 100 | 50 | 20 | 10 | 5 |
| 10 mg | 200 | 100 | 40 | 20 | 10 |
The labelled mass is not a guarantee of the mass in your vial: net content is a separate measurement from purity, and certificates on file often measure a few percent above or below the label.
No label sets a diluent volume for research-grade VIP, and the compound page states none, so the volume is a choice. The one decision with real consequences is resolution: a small quantity drawn from a strong solution sits at one or two units, where a one-unit misread is a large error, and the fix is more water. The technique is covered once, elsewhere: reconstituting peptides step by step and the bacteriostatic water guide. Storage and in-use guidance there is general peptide guidance, not a VIP-specific finding, and it does not cover nasal formulations.
VIP is not FDA-approved for any indication as of August 2026. Aviptadil, a synthetic VIP analog, has been through formal clinical development (including for COVID-19 respiratory failure) and is not FDA-approved in the United States; approval claims for aviptadil-containing combination products in some other countries could not be independently verified, so the compound page does not assert them (as of August 2026). Research-grade VIP is sold by third-party laboratories and is legal to purchase as a research chemical for laboratory use in most jurisdictions, but it is not approved for human consumption. Intranasal VIP in the CIRS framework operates as physician-directed compounding in some practice contexts, not under an FDA-approved indication.
Independent test records: VIP lab tests. Tracked prices: VIP price per milligram. Another peptide given as a nasal solution has its own page: the Selank calculator.
It depends on the concentration. A 10 mg vial with 2 mL of water is 10 ÷ 2 = 5 mg/mL, and 5 mg/mL × 0.1 mL = 0.5 mg, which is 500 mcg in every 0.1 mL. With 5 mL in the same vial it is 2 mg/mL, or 200 mcg in every 0.1 mL.
At the page default of 5 mg/mL (a 10 mg vial with 2 mL of water), each unit on a U-100 syringe carries 50 mcg, so 100 mcg is 2 units — small enough that a one-unit misread is a 50% error. With 5 mL in the same vial (2 mg/mL) it is 5 units. A units figure quoted without a concentration cannot be used.
There isn't one Peptigrity states, for any route. The compound page says research use varies by route, VIP is not approved for human consumption, and Peptigrity does not recommend a dose. This calculator converts a quantity you already have in mind into units or a volume; it does not supply the quantity.
This page cannot tell you without your pump's volume. The VIP compound page states no spray volume, and the micrograms per spray depend entirely on what your own pump delivers per actuation. Enter that volume in the nasal converter and it multiplies it by the concentration.
No. VIP is the native 28-amino-acid neuropeptide; aviptadil is a synthetic VIP analog developed for formal clinical use. They are mechanistically related but not identical products, and aviptadil is not FDA-approved in the United States.