Free Sermorelin reconstitution and dosage calculator. Enter vial size (2–15 mg), bacteriostatic water volume and target dose to get concentration, syringe units and doses per vial — or read the Sermorelin peptide guide for what the compound is.
A 5 mg vial of Sermorelin reconstituted with 2 mL of bacteriostatic water gives a concentration of 2.5 mg/mL, or 25 mcg per unit on a U-100 syringe. For a 100 mcg dose, draw the syringe to 4 units (0.04 mL). At that dose the vial provides about 50 doses.
Draw the syringe up to
That's one 200 mcg dose. Add 1 mL of water to your 2 mg vial first.
| Step | Dose | Draw on a U-100 | Doses per vial |
|---|---|---|---|
| Standard | 100 mcg | 5 units | 20 |
| Mid-range | 200 mcg | 10 units | 10 |
| Top of stated range | 300 mcg | 15 units | 6 |
Tap any row to load that dose into the calculator above.
Sermorelin is dosed in micrograms, not milligrams, so the draw is small: at the default 2.5 mg/mL, every 100 mcg is 4 units on a U-100 syringe. Peptigrity's Sermorelin science article states a standard range of 100–300 mcg per day subcutaneously, a split option of 100 mcg in the morning plus 100 mcg at night, and cycles of 8–12 weeks followed by a 4–6 week break. The calculator does the arithmetic only; it does not recommend a tier.
| Tier | Dose | Schedule | At 2.5 mg/mL | At 5 mg/mL | At 1 mg/mL |
|---|---|---|---|---|---|
| Standard, single injection | 100 mcg | Once daily, at bedtime | 4 units (0.04 mL) | 2 units (0.02 mL) | 10 units (0.1 mL) |
| Standard, split | 100 mcg + 100 mcg | Morning and night | 4 units per injection | 2 units per injection | 10 units per injection |
| Mid-range | 200 mcg | Once daily | 8 units (0.08 mL) | 4 units (0.04 mL) | 20 units (0.2 mL) |
| Top of the stated range | 300 mcg | Once daily | 12 units (0.12 mL) | 6 units (0.06 mL) | 30 units (0.3 mL) |
| Historical prescription (Geref, pediatric) | 30 mcg/kg | Subcutaneous daily | Weight-dependent — enter the mcg total in the calculator | — | — |
Standard, single injection: 100 mcg once daily at bedtime — draw 4 units (0.04 mL) at 2.5 mg/mL. Standard, split: 100 mcg morning and 100 mcg night — draw 4 units (0.04 mL) per injection at 2.5 mg/mL. Mid-range: 200 mcg once daily — draw 8 units (0.08 mL) at 2.5 mg/mL. Top of the stated range: 300 mcg once daily — draw 12 units (0.12 mL) at 2.5 mg/mL. The historical Geref pediatric dose was 30 mcg/kg subcutaneous daily; adult use is not FDA-approved and protocols vary.
Two qualifiers from the same source: peak IGF-1 is reported at 300 mcg per day with no added benefit beyond that figure, and the peak GH spike is reported 15–30 minutes after injection, which is why bedtime timing is described as aligning with the endogenous GH surge. Sermorelin's half-life is ~10–20 minutes, which is the reason the protocol is daily rather than weekly.
Sermorelin draws land between 2 and 30 units on a U-100 syringe across every combination the presets allow, so syringe choice matters more here than it does for a milligram-dosed compound. On a U-30 or U-50 syringe the same volume is easier to read: 4 units of a 2.5 mg/mL solution is 0.04 mL whatever the barrel, and a smaller barrel spreads that 0.04 mL over more visible graduations. Pick the dilution that puts your dose on a whole unit.
| Dose | 5 mg + 1 mL (5 mg/mL) | 5 mg + 2 mL (2.5 mg/mL) | 5 mg + 3 mL (1.67 mg/mL) | 10 mg + 2 mL (5 mg/mL) | 10 mg + 5 mL (2 mg/mL) |
|---|---|---|---|---|---|
| 100 mcg | 2 units | 4 units | 6 units | 2 units | 5 units |
| 200 mcg | 4 units | 8 units | 12 units | 4 units | 10 units |
| 250 mcg | 5 units | 10 units | 15 units | 5 units | 12.5 units |
| 300 mcg | 6 units | 12 units | 18 units | 6 units | 15 units |
At 2.5 mg/mL, a 100 mcg Sermorelin dose is 4 units, 200 mcg is 8 units and 300 mcg is 12 units. At 5 mg/mL those same doses are 2, 4 and 6 units. At 1.67 mg/mL they are 6, 12 and 18 units. A 10 mg vial reconstituted with 5 mL gives 2 mg/mL, where 250 mcg falls between graduations at 12.5 units — round the dilution, not the dose.
Sermorelin arrives as a lyophilised powder and is reconstituted with bacteriostatic water before use. The volume is a free choice: it sets the concentration and therefore the units you draw, but not how many doses the vial holds. The default of 2 mL into a 5 mg vial gives 2.5 mg/mL and puts the 100–300 mcg range on whole units. Full technique lives in the dedicated preparation articles rather than being repeated here.
Step 1 — Choose the diluent and the volume. Use bacteriostatic water, not plain sterile water, when the vial will be entered more than once; the difference, and when the preservative is contraindicated, is covered in the bacteriostatic water guide. For Sermorelin at 100–300 mcg, 2 mL into a 5 mg vial (2.5 mg/mL, 25 mcg per unit) is the volume that keeps every dose in the stated range on a whole unit.
Step 2 — Reconstitute. Follow the standard vial-to-syringe procedure in reconstituting peptides step by step: add the water slowly against the inside glass wall and swirl rather than shake.
Sermorelin's daily schedule and microgram doses mean a vial is measured in weeks, not months. A 5 mg vial at 100 mcg per day holds 50 doses, which is about 7.1 weeks — close to the low end of the 8–12 week cycle the science article describes. At 300 mcg per day the same vial lasts about 2.4 weeks. Duration depends only on the vial size and the daily total, never on the water volume.
| Vial | 100 mcg/day | 200 mcg/day | 300 mcg/day |
|---|---|---|---|
| 2 mg | 20 days (~2.9 weeks) | 10 days (~1.4 weeks) | ~6.7 days (~1.0 week) |
| 5 mg | 50 days (~7.1 weeks) | 25 days (~3.6 weeks) | ~16.7 days (~2.4 weeks) |
| 10 mg | 100 days (~14.3 weeks) | 50 days (~7.1 weeks) | ~33.3 days (~4.8 weeks) |
| 15 mg | 150 days (~21.4 weeks) | 75 days (~10.7 weeks) | 50 days (~7.1 weeks) |
A 5 mg vial of Sermorelin at 100 mcg daily lasts about 7.1 weeks. A 5 mg vial at 200 mcg daily lasts about 3.6 weeks. A 10 mg vial at 100 mcg daily lasts about 14.3 weeks. A 2 mg vial at 300 mcg daily lasts about one week. An 8–12 week cycle at 100 mcg daily needs roughly one 10 mg vial, or two 5 mg vials.
Sermorelin is a 29-amino-acid GHRH analog that stimulates pulsatile GH release from the pituitary. Ipamorelin reaches the same endpoint through the ghrelin receptor rather than the GHRH receptor; Tesamorelin is the other GHRH analog on the platform and the only one of the three currently marketed under an FDA approval. The regulatory and half-life differences are what change a protocol, so those are the rows below.
| Factor | Sermorelin | Ipamorelin | Tesamorelin |
|---|---|---|---|
| Class | 29-amino-acid GHRH analog | Selective ghrelin-receptor agonist (pentapeptide) | GHRH(1-44) analog, DPP-4 resistant |
| Regulatory status | FDA-approved as Geref, discontinued from the US market in 2008 | Not approved for any medical indication anywhere in the world as of August 2026 | FDA-approved as Egrifta (2010) for HIV-associated lipodystrophy |
| Half-life | ~10–20 minutes | ~2 hours | ~8 minutes per the current US label |
| Stated dose reference | 100–300 mcg/day SC; Geref pediatric 30 mcg/kg/day | No dose guidance published on the compound page | Egrifta label dose 2 mg SC daily |
Sermorelin and Tesamorelin are both GHRH analogs; Ipamorelin works through the ghrelin receptor instead. Deeper comparison: Ipamorelin vs Sermorelin vs Tesamorelin. Category context: the GH secretagogue category.
As of September 2026, Sermorelin is FDA-approved (Geref, discontinued from the US market in 2008) and is prohibited at all times under WADA Section S2.2.4, growth-hormone-releasing factors. Research-grade Sermorelin sold by third-party suppliers is not the prescription product; that material is supplied for research use only.
Independent test records for this compound: Sermorelin lab test records. Tracked prices: Sermorelin price per milligram. How the purity value is calculated: Purity Index.
It depends on the dilution. A 5 mg vial with 2 mL of bacteriostatic water is 2.5 mg/mL, or 25 mcg per unit, so 100 mcg is 4 units (0.04 mL) on a U-100 syringe. With 1 mL it is 2 units; with 3 mL, 6 units; with 5 mL, 10 units.
Any volume you can measure — it changes the concentration, not the number of doses. 2 mL gives 2.5 mg/mL and puts 100, 200 and 300 mcg on 4, 8 and 12 whole units. Use 1 mL for a smaller draw volume, 3 mL for wider graduations at low doses.
Peptigrity's Sermorelin science article states a standard range of 100–300 mcg per daysubcutaneously, with a split option of 100 mcg in the morning plus 100 mcg at night, and reports peak IGF-1 at 300 mcg per day with no added benefit above it. This calculator converts a dose to units; it does not recommend one.
The same source describes bedtime administration, to align with the endogenous GH surge, and reports the peak GH spike 15–30 minutes after injection. Sermorelin's half-life is ~10–20 minutes, which is why the published protocols are daily rather than weekly.
A 5 mg vial at 100 mcg daily is 50 doses, about 7.1 weeks; at 200 mcg daily, about 3.6 weeks. A 10 mg vial at 100 mcg daily is about 14.3 weeks. An 8–12 week cycle at 100 mcg daily takes roughly one 10 mg vial or two 5 mg vials.
As of September 2026, the Sermorelin compound page states it is FDA-approved as Geref, discontinued from the US market in 2008, and that it is available through 503A/503B compounding pharmacies on a physician's prescription. Research-grade material sold by third-party laboratories is not the prescription product.