Gonadorelin reaches people through two separate channels: compounded gonadorelin, dispensed by US compounding pharmacies (503A/503B) under physician prescription, and research-grade gonadorelin, sold as a research chemical for laboratory use. This calculator is a prescribing aid for neither. It converts a vial size and a water volume into a concentration and the micrograms carried by each unit on a U-100 syringe; a prescription's quantity comes from the prescriber, and Peptigrity states no gonadorelin dose. The compound itself is covered in the gonadorelin guide.
A 10 mg vial of Gonadorelin reconstituted with 2 mL of bacteriostatic water gives a concentration of 5.0 mg/mL, or 50 mcg per unit on a U-100 syringe.
Defaults: 10 mg is the most common labelled vial among the gonadorelin tests on file, 21 Sep 2026 (6 of 13); 2 mL was chosen for simple arithmetic and is not a sourced volume. Peptigrity publishes no Gonadorelin dose, so the dose field starts empty.
Draw the syringe up to
Enter your own amount to see the draw. Add 2 mL of water to your 10 mg vial first.
Gonadorelin has 13 independent lab tests on file at Peptigrity, averaging 99.59% HPLC purity across the tests that report one. Purity is not net content: a clean certificate confirms what is in a vial, not how much. See the Gonadorelin lab-test records.
The table sets out the two channels as the gonadorelin compound page describes them (last updated August 2026).
| Question | Compounded gonadorelin | Research-grade gonadorelin |
|---|---|---|
| Who supplies it? | US compounding pharmacies, under the 503A and 503B regulations | Research-chemical vendors, for laboratory use |
| On what basis? | Under physician prescription | Legal to purchase in most jurisdictions |
| Quality assurance | Pharmacy-grade, which the compound page says carries different quality assurance than research-grade material | Independent HPLC purity testing, with mass spectrometry to tell gonadorelin from GnRH analogs |
| Regulatory footing | Depends on an FDA regulatory status that has been in flux during 2024–2026 | Sold as a research chemical for laboratory use |
The lab record on this page is built from certificates that shops publish through their official channels. It describes the research-grade supply; it says nothing about a pharmacy's compounded product, and a pharmacy's quality assurance says nothing about a research vial.
Gonadorelin is a synthetic 10-amino-acid peptide identical to native gonadotropin-releasing hormone (GnRH). It acts on the pituitary GnRH receptor to release LH and FSH — and the compound page is explicit that the response is frequency-dependent, not simply dose-dependent: brief pulses raise LH and FSH, while continuous or high-dose receptor occupancy desensitizes the receptor and suppresses them. That is why therapeutic gonadorelin had to be given by pulsatile pump rather than as a steady infusion. An amount on its own therefore does not describe how gonadorelin is used, and the compound page declines to state one.
The table summarises what the gonadorelin compound page states (last updated August 2026).
| Question | What the compound page states | Evidence level |
|---|---|---|
| What is it? | A synthetic 10-amino-acid peptide identical in sequence to native GnRH (also LHRH) | Established endocrinology |
| Approved products? | Factrel (diagnostic, NDA 018123) and Lutrepulse (pulsatile ovulation induction, NDA 019687); Drugs@FDA lists both as discontinued | FDA-approved, discontinued |
| How is it given clinically? | Varies by indication — pulsatile pump infusion for fertility, intermittent subcutaneous use alongside TRT, a single IV dose for diagnostic evaluation | Clinical use, by indication |
| Half-life? | Short — 3 to 10 minutes for the native hormone | Established endocrinology |
| A dose from Peptigrity? | None — "Does Peptigrity recommend a Gonadorelin dose? No." | None — declined |
Gonadorelin acts one step downstream of kisspeptin, which stimulates the hypothalamic GnRH neurons that produce native GnRH. That peptide has its own conversion page: the kisspeptin calculator.
The table converts reference quantities to syringe units at the default of 5.0 mg/mL (10 mg of Gonadorelin in 2 mL), and counts how many draws of each a vial holds. Every row is arithmetic, not a dose: read the units for the amount you already intend to measure.
| Quantity | Draw at 5.0 mg/mL | Volume | Draws from a 2 mg vial | Draws from a 5 mg vial |
|---|---|---|---|---|
| 50 mcg | 1.0 units | 0.01 mL | 40 | 100 |
| 100 mcg | 2.0 units | 0.02 mL | 20 | 50 |
| 250 mcg | 5.0 units | 0.05 mL | 8 | 20 |
| 500 mcg | 10.0 units | 0.10 mL | 4 | 10 |
| 1 mg | 20.0 units | 0.20 mL | 2 | 5 |
The same Gonadorelin quantity lands on a different mark depending on how much water went into the vial. Read down the column for the concentration you actually mixed; a units figure carried across from another column is simply wrong.
| Quantity | At 10 mg/mL (10 mg + 1 mL) | At 5.0 mg/mL (10 mg + 2 mL) | At 2.0 mg/mL (10 mg + 5 mL) |
|---|---|---|---|
| 50 mcg | 0.5 units | 1.0 units | 2.5 units |
| 100 mcg | 1.0 units | 2.0 units | 5.0 units |
| 250 mcg | 2.5 units | 5.0 units | 12.5 units |
| 500 mcg | 5.0 units | 10.0 units | 25.0 units |
| 1 mg | 10.0 units | 20.0 units | 50.0 units |
Every cell is the same arithmetic: units = (quantity in mg ÷ concentration in mg/mL) × 100 on a U-100 syringe. More water spreads the same mass over more units, which is the fix when a small quantity would otherwise sit at two or three units, where a one-unit misread is a large error.
Each Gonadorelin vial holds as many draws as its labelled mass divided by the quantity per draw; the water volume changes nothing about it. The grid counts draws, not weeks — this page states no frequency.
| Vial size | At 50 mcg | At 100 mcg | At 250 mcg | At 500 mcg | At 1 mg |
|---|---|---|---|---|---|
| 2 mg | 40 | 20 | 8 | 4 | 2 |
| 5 mg | 100 | 50 | 20 | 10 | 5 |
| 10 mg | 200 | 100 | 40 | 20 | 10 |
The labelled mass is not a guarantee of the mass in your vial: net content is a separate measurement from purity, and certificates on file often measure a few percent above or below the label.
No label sets a diluent volume for research-grade gonadorelin, and the compound page states none, so the volume is a choice. The one decision with real consequences is resolution: a small quantity drawn from a strong solution sits at one or two units, where a one-unit misread is a large error, and the fix is more water. The technique is covered once, elsewhere: reconstituting peptides step by step and the bacteriostatic water guide. Storage and in-use guidance there is general peptide guidance, not a gonadorelin-specific finding — and a compounded product comes with its pharmacy's own instructions, which this page does not replace.
Two gonadorelin products were FDA-approved, and both are now listed as discontinued in Drugs@FDA. Factrel (gonadorelin hydrochloride, NDA 018123) was approved on September 30, 1982 for the diagnostic evaluation of pituitary gonadotropic function. Lutrepulse (gonadorelin acetate, NDA 019687, an orphan drug) was approved on October 10, 1989 as a pulsatile-infusion therapy to induce ovulation in women with primary hypothalamic amenorrhea. The FDA record gives no date or reason for either discontinuation. Gonadorelin is currently available in the US through compounding pharmacies under 503A and 503B, with that pathway depending on an FDA regulatory status that has been in flux during 2024–2026. Internationally, gonadorelin has approved status in several jurisdictions for fertility and hypogonadism indications.
Independent test records: gonadorelin lab tests. Tracked prices: gonadorelin price per milligram. The upstream peptide has its own page: kisspeptin calculator.
It depends on the concentration. At the page default of 5 mg/mL (a 10 mg vial with 2 mL of water), each unit on a U-100 syringe carries 50 mcg, so 250 mcg is 5 units (0.05 mL). With 5 mL in the same vial (2 mg/mL) it is 12.5 units. A units figure quoted without a concentration cannot be used.
There isn't a single one, and Peptigrity does not recommend a dose. The compound page says clinical use varies by indication — pulsatile pump infusion for fertility, intermittent subcutaneous use alongside TRT, a single IV dose for diagnostic evaluation — and that the response depends on the pattern of delivery, not simply the amount. A compounded prescription's quantity is set by the prescriber, not by a calculator.
No. Compounded gonadorelin is dispensed by US compounding pharmacies (503A/503B) under physician prescription and carries pharmacy-grade quality assurance. Research-grade gonadorelin is sold as a research chemical for laboratory use, and its quality signal is independent HPLC and mass-spectrometry testing. The lab record on this page covers certificates published by shops, not pharmacy products.
Historically, yes — two products. Factrel was approved in 1982 for diagnostic evaluation of pituitary function, and Lutrepulse in 1989 for pulsatile ovulation induction. Drugs@FDA now lists both as discontinued and gives no date or reason. Gonadorelin remains available in the US through 503A/503B compounding pharmacies.
Gonadorelin acts at the pituitary GnRH receptor. Kisspeptin acts one step upstream, stimulating the hypothalamic GnRH neurons that produce native GnRH. They are different molecules with separate calculator pages.