CJC-1295 without DAC lab tests

CJC-1295 without DAC, also sold as Mod GRF 1-29 or Modified GRF (1-29), is GHRH(1-29) carrying four substitutions — D-Ala2, Gln8, Ala15, Leu27 — and a C-terminal amide: 29 amino acids, CAS 863288-34-0 (PubChem CID 56841945), formula C₁₅₂H₂₅₂N₄₄O₄₂, molecular weight 3,367.9 g/mol, half-life about 30 minutes. The DAC form uses the same backbone plus a thirtieth lysine bearing a maleimidopropionyl group that binds covalently to circulating albumin, which moves the mass to about 3,647 Da and the half-life to roughly 5.8–8.1 days. Both are sold under the unqualified name "CJC-1295".

Mass spectrometry separates the two forms trivially across the roughly 280-dalton gap; no HPLC purity figure addresses it. Sermorelin is the harder discrimination: native GHRH(1-29) sits just 10 daltons below the no-DAC form at 3,357.9, close enough that a nominal mass on a low-resolution instrument will not settle it. The useful request there is a high-resolution result reporting elemental composition rather than a single rounded number, since the four substitutions, including Leu27, change the composition rather than merely the mass.

The human data routinely attached to the name belongs to the DAC form. The two trials usually cited — Teichman 2006 and Ionescu and Frohman 2006, both in JCEM — used it, and the 2- to 10-fold GH elevation, the 1.5- to 3-fold IGF-1 rise and the 5.8–8.1 day half-life are its figures. No published human study of the no-DAC form exists, so a no-DAC listing carrying those numbers has combined two products in one description.

Five distinct substances exist under the name: the free base, the acetate, the DAC free base, the DAC acetate and the DAC trifluoroacetate. PubChem's CJC-1295 records carry conflated synonyms, with DAC and no-DAC names attached to the same structure, so a screenshot of a database entry is not an identity result for a batch. Each form's purity figures are in its own COA benchmarks; a purity figure says nothing about whether the form was correctly identified, and a high purity number with no mass result is compatible with receiving the wrong form in excellent condition.

• Mass near 3,367.9 Da on a batch-matched certificate; roughly 3,647 Da is the DAC form.
• A name qualified as "without DAC" or "Mod GRF 1-29"; an unqualified "CJC-1295" is an ambiguous description, not a specification.
• CAS 863288-34-0 and the salt form stated; a DAC CAS printed under a no-DAC listing is a direct contradiction on the page.
• A printed molecular weight of 3,367.9 g/mol, C₁₅₂H₂₅₂N₄₄O₄₂. A no-DAC listing showing 3,645.9 or ~3,647 has copied a DAC figure.
• To exclude sermorelin (3,357.9 Da), high-resolution MS reporting elemental composition — a 10-dalton gap treated as within tolerance is a red flag.