2-peptide research blend in one vial: Sermorelin + Ipamorelin. A "clean" GH secretagogue stack pairing the GHRH(1-29) analog Sermorelin with Ipamorelin — the most selective GHRP, with minimal cortisol, prolactin, or appetite effects.
A blend has one whole-vial purity, but the number that decides what you're holding is the net content of each component — an HPLC run resolves a separate peak for each. So we verify Sermorelin + Ipamorelin component by component. Each links to its own compound page, where its full independent testing lives.
| Component | Typical mg | Role in the blend | Verified purity | |
|---|---|---|---|---|
| Sermorelin | varies | GHRH(1-29) analog — raises GH pulse amplitude | 99.3% · 226 tests | View testing → |
| Ipamorelin | varies | Most selective GHRP — minimal cortisol, prolactin or hunger | 99.7% · 439 tests | View testing → |
Composition varies by vendor. The components above are consistent across shops, but the milligrams and ratio are not — always dose by the individual component amounts printed on your vial, never by a generic “blend dose.”
A blend is the single hardest product to trust — the whole-vial purity tells you the material is clean, but not whether every peptide is present in the right amount. Two questions decide that, and both are answerable in a lab.
Mass spec (or a clean HPLC peak per compound) confirms each peptide is in the vial — not one short, not a cheaper substitute standing in for the expensive one.
Tested milligrams vs. labelled milligrams, per component. This is where blends fail quietly — one component underdosed to pad margin while the vial still “contains” everything.
Tests run on a Sermorelin + Ipamorelin vial as sold — broken down per component. This is the data no shop and no competitor publishes.
| Component | Labelled | Net content (tested) | Identity (LC-MS) | Vs. label |
|---|---|---|---|---|
| Sermorelin | 5 mg | 5 mg | ✓ present | Within (+0%) |
| Ipamorelin | 5 mg | 5 mg | ✓ present | Within (+0%) |
Until more Sermorelin + Ipamorelin vials are tested, the strongest signal is how each component performs in single-compound testing across the shops we track. Tap any card for its full data.
Last Updated: August 2026
Last Updated: August 2026
This is the "cleanest" of the GH secretagogue pairings: Sermorelin (GHRH analog) with Ipamorelin (the most selective GHRP). It is research-use-only as a combination, not an approved product, and WADA-prohibited.
Sermorelin raises GH pulse amplitude while Ipamorelin, the most selective ghrelin-receptor agonist, raises pulse frequency and suppresses somatostatin for synergistic GH release — with Ipamorelin's defining feature being selectivity: little to no rise in cortisol, prolactin, or appetite, which is why this pairing is often described as the "clean" GH stack. No controlled clinical trial of the Sermorelin + Ipamorelin blend has been published as of August 2026; the "clean stack" case — a GHRH analog raising GH pulse amplitude while a selective ghrelin mimetic raises pulse frequency — is a mechanistic rationale, not a clinically-validated combined outcome.
Neither component is an approved product in this combination. Sermorelin was formerly FDA-approved as Geref in two forms — a diagnostic agent (NDA 019863, 1990) and a pediatric growth-hormone-deficiency treatment (NDA 020443, 1997) — both discontinued in 2008 for commercial reasons; the FDA determined in 2013 that Geref was not withdrawn for reasons of safety or effectiveness, and sermorelin is today available only through compounding. Ipamorelin was never approved for any indication; ipamorelin acetate remains in Category 2 of the FDA's bulk-drug-substances evaluation (the 503B outsourcing-facility route), was not among the twelve peptides removed from Category 2 in April 2026, and is not on the Category 1 list eligible for compounding, as of August 2026. In sport, both are prohibited at all times by the World Anti-Doping Agency under Section S2.2.4 (growth-hormone-releasing factors and secretagogues). Verify each labeled component's identity and purity via HPLC and mass-spec. Peptigrity collects independent third-party Certificates of Analysis for Sermorelin + Ipamorelin from shops' official channels and verifies each for authenticity before publishing. Because shops choose which COAs to publish, results reflect the batches shops have made public rather than every production batch — a selection bias we state openly. A community-funded Testing Grant to purchase and test vials anonymously is in development. Tests in the database come from independent labs such as Janoshik Analytical, Freedom Diagnostics, and Chromate. The shop trust score weights lab purity and reviews equally (50/50). See how to read lab results.
Educational information only; not medical advice. This is a research-use-only stack, not an approved therapy. Consult a qualified healthcare provider. Peptigrity does not sell, endorse, or recommend products or vendors.
In a blend you can only set the dose of one component — the rest follow the fixed ratio. Our calculator does that math so you don't underdose the peptide you actually care about.
Enter each component's milligrams and your BAC water — get per-component units for one syringe draw.
Open the blend calculator →How much bacteriostatic water, mixing without shaking, storage, and shelf life once mixed.
Read the reconstitution guide →Because Ipamorelin is the most selective GHRP — it stimulates GH with minimal cortisol, prolactin, or appetite effects.
GHRP-2 and GHRP-6 are more potent but less selective (more cortisol/prolactin or hunger); Ipamorelin trades some potency for a cleaner profile.
As a combination it is not an approved product; research-market material is RUO, and Ipamorelin is banned in sport (WADA). Verify local rules.
No. Peptigrity is an independent review platform, not a medical authority.